Tumor Microenvironment Inflammation and Obesity in Advanced Prostate Cancer
Abstract
Background: The goal of this pilot study was to examine the relationship between inflammation markers in the tumor microenvironment and PCa outcomes by obesity status. Methods: We selected 75 obese and 75 non-obese patients from the Study of Clinical Outcomes, Risk and Ethnicity. Sufficient paraffin-embedded prostatectomy tissue from 99 patients was available for pathology studies. Tumor samples were cut, deidentified, stained, imaged, and analyzed for cell type and count. We linked T cells and macrophages (TILS) to clinical and demographic data. Statistical analyses included frequency tables, Kruskal-Wallis tests, Spearman correlations, and multivariable models. Results: We observed univariate associations between increased CD68 cells and tumor grade (p=0.019) and biochemical failure (p=0.033). In multivariable analyses, CD3 (HR=0.93, 95% CI= 0.88-0.99) and CD8 counts (HR=1.08, 95% CI=1.01-1.17) were associated with biochemical failure. There were no differences in TILS by obesity. Conclusion: TILS did not differ by obesity status. However, inflammation markers were associated with poor PCa outcomes. Further examination of underlying mechanisms that influence obesity-related effects on PCa outcomes is warranted.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 30, 2015
- Accession Number
- AD1001439
Entities
People
- Charnita M Zeigler-Johnson
Organizations
- Thomas Jefferson University