Understanding Tumor Dormancy as a Means of Secondary Prevention

Abstract

The purpose of this collaborative project is to establish a molecular definition of the dormant state of a cancer cell. In doing this we hope to understand how this dormancy is broken, ultimately leading to recurrence in a patient that was stably in remission. Once our understanding of this is more complete it is hoped that we can devise strategies for secondary prevention. This funding year we have developed new methods to track dormant cells in vivo, which will also help with RNA extraction and thus transcriptome sequencing. We have also modified our methods to construct mice with markers for tumor niche cells, using the latest technology, and progressed with our work on single chain antibodies, with the intention to use these to identify dormant cells in human biopsies.

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Document Details

Document Type
Technical Report
Publication Date
Oct 14, 2015
Accession Number
AD1001597

Entities

People

  • Gregory Hannon

Organizations

  • Cold Spring Harbor Laboratory

Tags

DTIC Thesaurus Topics

  • Antibodies
  • Biomedical Research
  • Breast Cancer
  • Cancer
  • Cell Line
  • Cells
  • Chemistry
  • Culture Techniques
  • Department Of Defense
  • Environment
  • Extraction
  • Fluorescent Dyes
  • Gene Expression
  • Medical Personnel
  • Neoplasms
  • Proteins
  • Tissues

Readers

  • Oncology (Cancer Research).
  • Systems Analysis and Design