Early Diagnosis and Intervention Strategies for Post-Traumatic Heterotopic Ossification in Severely Injured Extremities

Abstract

This study will recruit wounded warriors with severe extremity trauma, which places them at high risk for heterotopicossification (HO); bone formation at abnormal sites, which causes pain, limits motion and/or limits the use of a prostheticdevice. There are three goals: 1) to understand the mechanisms involved in HO; 2) to define accurate and practical methods topredict where HO will develop; and 3) to define potential therapies for prevention or mitigation of HO.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1001732

Entities

People

  • George Muschler
  • Jonathan Forsberg
  • Tom Davis

Organizations

  • Geneva Foundation

Tags

DTIC Thesaurus Topics

  • Amputees
  • Blood
  • Casualties
  • Cells
  • Chemistry
  • Connective Tissue
  • Data Analysis
  • Gene Expression
  • Growth Factors
  • Heterotopic Ossification
  • Osteogenesis
  • Peptide Growth Factors
  • Peptides
  • Prosthetics
  • Proteins
  • Therapy
  • Transcription Factors

Fields of Study

  • Medicine

Readers

  • Aerial Delivery - Logistics and Supply Chain Management.
  • Neurotrauma and Rehabilitation Medicine.