Preclinical Testing of a New MR Imaging Approach to Distinguish Aggressive from Indolent Disease
Abstract
The aim of this project was to develop a new MRI approach to characterize aggressive prostate cancers and differentiate them from low grade tumors based on genetic/proteomic induced metabolic differences and perfusion abnormalities. The project was designed to then apply this new approach in preclinical transgenic prostate cancer models to obtain the required preliminary data for future clinical trials. This project has gone extremely well accomplishing the technical milestones described in the original approved Statement of Work (SOW) and performing the unprecedented prostate cancer model studies demonstrating the ability of these new methods to measure significantly different metabolic and perfusion parameters inaggressive high grade cancers compared to low grade. The results of this project demonstrate feasibility and strongly support the hypothesis that this new approach can distinguish aggressive from indolent prostate cancer. This project has resulted in new technical advances and the strong preclinical data that will serve as the basis for justifying and designing future clinical trials investigating their value in patients with prostate cancer.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2015
- Accession Number
- AD1001742
Entities
People
- Daniel B. Vigneron