Spinal Cord Swelling and Alterations in Hydrostatic Pressure After Acute Injury
Abstract
In Year 1 of this award we examined whether duraplasty after acute thoracic spinal cord injury (SCI) in a porcine model could improve long-term functional outcome after injury. The T10 spinal cord was contused with a weight drop device in which a 50g weight impact rod was dropped from a 20-cm height followed by 5 minutes compression (150g). Following injury, in n=6 animals a C6-T13 transverse dural incision was performed and a 10x1 cm artificial dural graft was sutured to the remaining dura mater in a watertight manner using a running suture of 6-0 Prolene, including the use of fibrin sealant to reinforce sutures. Control animals received an identical spinal cord contusion, however without expansile duraplasty. Behavioral and functional testing was performed weekly up to 12 weeks post-injury using the Porcine Thoracic Injury Behavior Scale and hindlimb SSEP monitoring. Preliminary data suggest that duraplasty surgery might improve functional recovery early after SCI compared to SCI-animals without duraplasty
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1001787
Entities
People
- Brian K Kwon
Organizations
- University of British Columbia