Translational Advancement of Somatostatin Gene Delivery for Disease Modification and Cognitive in Intractable Epilepsy

Abstract

The objective of the current study was to test whether intracranial delivery of neuropeptide somatostatin (SST) vector could similarly suppress seizures when delivered after a stable seizure state was established. We tested the hypothesis that the serotype 5 AAV vector-mediated overexpression of SST in vivo reduces the severity of seizures in the rodent amygdala electrical kindling model of temporal lobe epilepsy (TLE).

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
AD1002313

Entities

People

  • Brandi K. Ormerod
  • Michael A. King
  • Paul R. Carney

Organizations

  • University of Florida

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Research
  • Brain
  • Brain Injuries
  • Cells
  • Diseases
  • Electrodes
  • Epilepsy
  • Gene Delivery
  • Gene Therapy
  • Genetics
  • Hippocampus
  • Implantation
  • Inflammation
  • Medical Personnel
  • Neurodegeneration
  • Neurogenesis
  • Neurosciences
  • Standards
  • Stem Cells
  • Students
  • Therapy
  • Virotherapy

Readers

  • Molecular Genetics
  • Neuroscience