Stress Altered Stem Cells with Decellularized Allograft to Improve Rate of Nerve Regeneration

Abstract

The research detailed in this annual report is to study how to improve the rate of peripheral nerve regeneration. The slow rate of nerve regeneration in limbs results in poor prognosis for patients suffering from severe injuries, leading to muscle impairment, and in extreme cases, atrophy. For our research, we will study the rate at which nerves regenerate in a rat model. We will excise the peripheral nerve, and study how to modulate the nerve regeneration through the use of a decellularized nerve graft and stress altered cells (SACs), a cell type we have identified that show stem-cell like qualities after undergoing physical and chemical stresses.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2014
Accession Number
AD1002595

Entities

People

  • Charles A. Vacanti
  • Koji Kojima

Organizations

  • Brigham and Women's Hospital

Tags

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Blood
  • Blood Cells
  • Cells
  • Culture Techniques
  • Governments
  • Health Services
  • Local Governments
  • Medical Personnel
  • Patent Applications
  • Peripheral Nervous System
  • Professional Development
  • Sciatic Nerve
  • Stem Cells
  • Transplants

Readers

  • Immunology and Pathology
  • Neuroscience
  • Trauma Surgery or Emergency Medicine.

Technology Areas

  • Biotechnology