Prostate Cancer Pathology Resource Network
Abstract
The Prostate Cancer Pathology Resource Network (which has since been renamed the Prostate CancerBiorepository Network or PCBN) is a collaboration between the Johns Hopkins School of Medicine (JHU) and the New York University School of Medicine (NYU). This Final Report covers the initial 3 year funding period plus a 4th bridge year that was awarded by DOD-PCRP to allow PCBN to submit a competitive renewal application in response an RFA that was delayed. The PCBN has developed a biorepository with high quality, well annotated specimens that can be used by prostate cancer researchers. Specimens include prostatectomy tissues (frozen, paraffin embedded, and tissue microarrays (TMAs), serum, plasma, buffy coat, prostatic fluid, and derived specimens (DNA, RNA, and protein); these specimens are linked to clinical and outcome data and supported by an informatics infrastructure. In addition to providing specimens the PCBN provides technical advice to researchers and performs independent biospecimen science research. The PCBN is currently made accessible to outside researchers through a website. Funding for the PCBN began June 2010, and it has been open to researchers since July 1 2011. In addition to the large number of biospecimens made available to the research community, other accomplishments include creation of a website to facilitate access and specimen requests, high impact publications citing use of PCBN specimens, biospecimen science describing optimized methods for RNA extraction and comparison of RNA quality from open vs. robot assisted radical prostatectomy, hosting a symposium with researchers from around the country to discuss issues and advances in biomarker and biospecimen research, and assembling a consortium among JHU, NYU, Memorial Sloan Kettering and University of Washington that successfully collaborated on a PCBN competitive renewal application.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 2015
- Accession Number
- AD1002605
Entities
People
- Bruce J Trock
Organizations
- Johns Hopkins University