Salivary Proteomic and microRNA Biomarkers Development for Lung Cancer Detection

Abstract

This is a lung cancer biomarker development project to test the hypothesis that there are discriminatory miRNA and proteomic biomarkers in saliva that can detect lung cancer with the aim to reduce the number unnecessary diagnostic workups (bronchoscopy) in patients with suspicious chest symptoms. Preliminary data is in place to support that our salivary biomarker technologies can discover and validate lung cancer biomarkers in saliva. The major goal is to perform a properly powered biomarker discovery and definitive validation of salivary proteomic and miRNA biomarkers for detection of lung cancer based on PRoBE design principles (prospective-specimen collection and retrospective-blinded-evaluation). The outcome of this three-year proposal will be a panel of definitively validated non-invasive saliva-based proteomic and micro-RNA biomarkers for detection of lung cancer.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 2015
Accession Number
AD1002614

Entities

People

  • David T. Wong

Organizations

  • University of California, Los Angeles

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Body Fluids
  • Cancer
  • Cells
  • Cellular Structures
  • Chemistry
  • Data Analysis
  • Data Sets
  • Detection
  • Diseases And Disorders
  • Environment
  • Health Services
  • Neoplasms
  • Rna Sequence Analysis
  • Stem Cells
  • Validation

Readers

  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology