Prevention of Stimulant Induced Euphoria with an Opioid Receptor Antagonist

Abstract

The protocol, sponsored by the Department of Defense, is a 6-week study examining whether methylphenidate-induced euphoria can be attenuated by co-administration with naltrexone in medication naive young adults (age 18-30) who exhibit a euphoric response to methylphenidate administered on the Drug Feeling Visit. In this double-blind study, subjects will received methylphenidate and naltrexone or a placebo to treat their ADHD symptoms over the course of the 6-week trial. We have completed the clinical trial and have begun the analysis phase. We are in the process of requesting a no cost extension to permit further analysis of primary and important secondary outcome and prepare presentations and manuscripts.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1002619

Entities

People

  • Anna Hall
  • Maribel Galdo
  • Thomas J. Spencer

Organizations

  • Massachusetts General Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Attention Deficit Disorder
  • Department Of Defense
  • Diseases And Disorders
  • Electrocardiography
  • Electronic Mail
  • Enlisted Personnel
  • Euphoria
  • Health Services
  • Infection
  • Medical Personnel
  • Military Families
  • Military Personnel
  • Pain
  • Physicians
  • Psychiatry
  • Social Security
  • Text Messaging

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