Targeting B7x and B7 H3 as New Immunotherapies for Prostate Cancer

Abstract

We have made good progress during the current funding period. We have established systems to generate humanand mouse B7-H3 fusion proteins and then used them to immunize B7-H3 gene knock mice. Two of immunized B7-H3-/- micegenerated good anti-B7-H3 antibodies in the blood and therefore one of these mice were used to generate hybridomas. Wealso have developed FACS-based approach to screen hybridomas and to exclude cross-reactive hybridomas. Finally, we havegenerated eight B7-H3-specific mAbs.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
AD1002635

Entities

People

  • Xingxing Zang

Organizations

  • Albert Einstein College of Medicine

Tags

DTIC Thesaurus Topics

  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Health Services
  • Lymphatic System
  • Lymphocytes
  • Medical Personnel
  • Oncology
  • Proteins

Fields of Study

  • Biology

Readers

  • Immunology
  • Oncology (Cancer Research).
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Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech