Restoring Bladder Function by Spinal Cord Neuromodulation in SCI

Abstract

The central objective of this project is to use non-invasive neuromodulation that can produce improved bladder function by enabling the function of spared circuitry in the spinal cord. This normalization of the spinal cord function is accomplished through a process of functional neuroplasticity whereby neuromodulation (e.g. electromagnetic stimulation) activates spinal circuits associated with micturition. It also facilitates ascending projections for improved sensation and descending projections for volitional voiding. A subset of subjects appears to experience long-lasting improvements and can void in the absence of stimulation. A total of 18 male/female, age 18+, >1 year post (C2-T8, non-conus) injury with complete but stable severe motor paralysis (ASIA A, B) and catheterization dependent for urination will be enrolled.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1002689

Entities

People

  • Daniel C. Lu

Organizations

  • University of California

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animal Structures
  • Cells
  • Embryos
  • Health Services
  • Medical Personnel
  • Neurons
  • Neuroplasticity
  • Peptide Growth Factors
  • Spinal Cord
  • Stem Cells

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.

Technology Areas

  • Biotechnology