Developing ER Stress Inhibitors for Treating ALS
Abstract
We have developed ASK1 inhibitors for the reduction of ER stress and the treatment of ALS. These compounds were screened in cellular models ALS and lead compounds were assessed in zebrafish models of ER stress. Two lead compounds were identified that are protective against ER stress-induced neuronal death. ALS mouse models were treated with compounds that modulate neuronal signaling and demonstrate favorable pharmacokinetics, however; no significant differences in age of symptom onset or survival were observed. Testing and development of these compounds is ongoing.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2015
- Accession Number
- AD1002708
Entities
People
- Nicholas Cosford
Organizations
- Sanford Burnham Prebys Medical Discovery Institute