Development of a Guinea Pig Lung Deposition Model

Abstract

Guinea pigs have been used as a surrogate for humans in a number of inhalation toxicology studies by exposing the animals to airborne viruses, biological agents, and other chemicals. Findings from these studies can be extrapolated to humans based on a particular dose-metric of interest to determine potential health effects in humans. In the absence of exposure-dose data, mathematical models can be developed for the transport and deposition of inhaled particles in the lungs of guinea pigs to allow for predictions of lobar, regional, and local deposition of particles.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 2016
Accession Number
AD1002742

Entities

People

  • Bahman Asgharian

Organizations

  • Applied Research Associates (United States)

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Equations
  • Flow Rate
  • Fluid Dynamics
  • Graphical User Interface
  • Laboratory Animals
  • Lung
  • Macrophages
  • Measurement
  • Nose
  • Particle Size
  • Particles
  • Pressure Distribution
  • Public Health
  • Respiration
  • Respiratory Physiological Phenomena
  • Rodents

Fields of Study

  • Biology

Readers

  • Aerosol Science/Aerosol Physics
  • Computational Modeling and Simulation
  • Toxicology/Environmental Toxicology