Reversing Maladaptive Plasticity to Cure Autonomic Dysreflexia after Spinal Cord Injury
Abstract
Autonomic dysreflexia (AD) is a potential life threatening condition characterized as episodic vascular hypertension (often with bradycardia) that develops in most people with a spinal cord injury (SCI) above thoracic spinal level T5. Using telemetric recording we were able to detect biphasic spontaneous AD developed in mice with T3 SCI; the early phase of AD occurs within first week which is likely due to loss of descending control of sympathetic outflow and the late phase occurs weeks post injury which is likely caused by the formation of aberrant sympathetic neural circuits at the site of injury. We proposed that post-injury inhibition of reactive synaptogenesis would block the onset or reduce the severity of AD.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1002993
Entities
People
- Hayes Davis
- Phillip Popovich
- Yan Wang
- Zhen Guan
Organizations
- Ohio State University