Development of Targeted Nanobubbles for Ultrasound Imaging and Ablation of Metastatic Prostate Cancer Lesions

Abstract

In this project, we developed the amphiphilic PEG-b-(PAA)-b-P(HDFMA-co-MMA) copolymers that can encapsulate PFP or PFH forming nanodroplets (~200 nm). Combining these nanodroplets with histotripsy proved to generate a cavitation bubble cloud with similar behavior but lower pressure compared to histotrIpsy itself. We investigated physical mechanisms underlying the nanodroplet cavitation process with playing different transducer frequencies (0.345, 0.5, 1, 3 MHz), changing the core PFC (PFP: boiling point 29 C or PFH: boiling point 56 C)and as well as cavitation nucleation is caused by the negative pressure (p-) exposed to the PFC. Under the light of these findings we established nanodroplet mediated histotripsy cell cavitation on 3D prostate cancer spheroid models.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1002998

Entities

People

  • Mohamed E. El-sayed

Organizations

  • University of Michigan

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Ablation
  • Acoustic Waves
  • Alkenes
  • Block Copolymers
  • Blood
  • Blood Cells
  • Boiling
  • Boiling Point
  • Chemical Synthesis
  • Chemistry
  • Copolymers
  • Frequency
  • High Pressure
  • Neoplasms
  • Phase Transformations
  • Polymers
  • Prostate Cancer

Readers

  • Medical Imaging.
  • Underwater engineering and Marine Technology.

Technology Areas

  • Microelectronics