Novel Approaches to Shock Induced Acute MODS
Abstract
Trauma-hemorrhagic shock (T/HS) is a major consequence of battlefield injury as well as civilian trauma and one of the major causes of death in these patients is the multiple organ dysfunction syndrome or MODS. Although the exact cause of MODS is incompletely understood, it appears related to normal body responses getting out of control resulting in the excessive activation of this research is to better understand the triggers that cause MODS and to test new therapies directed at controlling these over active and hence tissue-inurious pathways. Two major significant observations were made during the funding period. 1) These results validated the hypothesis that the biologic factors that start the process leading to MODS originated from the stressed intestine and/or its contents and that these factors reached the systemic circulation via the intestinal lymphatic system. 2) Secondly, we documented that the drug C1inh given after the shock-trauma insult, as part of the volume resuscitation regimen, limited to some extent T/HS-induced MODS.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 2014
- Accession Number
- AD1003004
Entities
People
- Edwin A. Deitch
Organizations
- University of Medicine and Dentistry of New Jersey