ETS Gene Fusions as Predictive Biomarkers of Resistance to Radiation Therapy for Prostate Cancer
Abstract
The research goals of this grant proposal are to: 1) investigate the effect of ETS gene fusions on radiation phenotype in preclinical models of prostate cancer, 2) to explore the mechanism of interaction between ERG (the predominant ETS gene fusion product) and the DNA repair protein DNA-PK, and 3) to determine if ETS gene fusion status is a clinical biomarker of radioresistance for prostate cancer. The training goals of this grant proposal included a series of regular meetings with mentors, research seminars, journal clubs, and workshops, all of which are intended to help Dr. Feng develop as a translational scientist. This grant proposal was approved as a five-year award; the current annual report summarizes accomplishments over the fifth year of the grant, from July 15, 2014 to July 15, 2015. Overall, this grant effort has been very successful. The work accomplished as a result of this grant resulted in seven publications in very high-impact journals, five presentations, and five grants (three from the Prostate Cancer Foundation, one from Celgene, and one from the Fund for Cancer Research). Additionally, Dr. Feng has met the training achievements specified in his original grant.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1003031
Entities
People
- Felix Y. Feng
Organizations
- University of Michigan