Early Recognition of Chronic Traumatic Encephalopathy Through FDDNP PET Imaging

Abstract

The PET biomarker, F-FDDNP (2-(1-{6-[(2-[F-18]fluoroethyl(methyl)amino]-2-naphthyl}ethylidene) malononitrile) [FDDNP] has shown sensitivity for in vivo detection of tau in addition to -sheet-containing brain amyloid neuroaggregates. Tau protein in a characteristic distribution is felt to be the cardinal pathologic feature of Chronic Traumatic Encephalopathy. This project will examine whether FDDNP PET imaging correlates with, and/or can predict, decline in cognitive function in those exposed to cumulative head trauma. Enrollment of subjects began in March, 2015, with 19 FDDNP PET images completed. Image quality has been excellent and quantitative analyses will begin when 50% of the subjects are completed. Enrollment has been delayed due to several unavoidable factors, but it is expected that all baseline imaging will be completed by summer, 2016.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1003204

Entities

People

  • Charles Bernick

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biological Markers
  • Biomedical Research
  • Blast Injuries
  • Brain Diseases
  • Brain Injuries
  • Central Nervous System Diseases
  • Chronic Encephalopathy
  • Craniocerebral Trauma
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Medical Personnel
  • Positron Emission Tomography
  • Positron Emissions
  • Recognition
  • Sensitivity

Fields of Study

  • Medicine

Readers

  • Medical Imaging.
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.