Preventing Ototoxic Synergy of Prior Noise Trauma During Aminoglycoside Therapy

Abstract

Exposure to loud sounds causes temporary or permanent threshold shifts in auditory perception, with reversible or irreversible cellular damage in the cochlea. Noise trauma, or loud sound exposure, is particularly associated with military environments, especially when sustaining blast injuries. These injuries are frequently treated with aminoglycoside antibiotics that have broad-spectrum bactericidal activity for treating or preventing life-threatening infections. However, aminoglycosides are also toxic to the cochlea, leading to hearing loss and further degradation from pre-injury status.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2014
Accession Number
AD1003211

Entities

People

  • Hongzhe Li

Organizations

  • Oregon Health & Science University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Anti-Bacterial Agents
  • Auditory Perception
  • Biomedical Research
  • Cell Physiological Processes
  • Cellular Structures
  • Confocal Microscopy
  • Data Analysis
  • Ear
  • Health Services
  • Hearing Disorders
  • Hearing Loss
  • Infection
  • Medical Personnel
  • Organ Of Corti
  • Otorhinolaryngology
  • Ototoxicity
  • Rodents

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Immunology