Vitamin D Supplementation for Prevention of Post-Traumatic Osteoarthritis: Evaluation in Animal and Clinical Models
Abstract
The goals of this translational study are to create an animal model of joint injury and evaluate the impact of Vitamin D in prevention and progression of PTOA. Concurrently, we will evaluate a clinical cohort of USMA cadets treated for ACL tear, with pre- and post-injury serum 25-hydroxy-Vitamin D levels and correlation with joint space narrowing and biomarkers of cartilage injury. If Vitamin D supplementation can prevent the onset of often rapid joint destruction that occurs with PTOA, this simple and safe intervention could potentially translate to pre-emptive treatment in high-risk military occupations. In addition, Vitamin D could be used at the time of injury to possibly mitigate ongoing articular cartilage damage.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1003345
Entities
People
- Jennifer M. Wolf
Organizations
- University of Connecticut