Therapeutic Efficacy of the Small Molecule GS-5734 against Ebola virus in Rhesus Monkeys
Abstract
The ongoing 2013-15 Ebola virus outbreak in West Africa unprecedented in the number of cases and fatalities, the geographic distribution, and the number of nations affected has highlighted the critical need for safe, effective, and readily available antiviral agents for treatment and prevention of acute Ebola virus (EBOV) disease (EVD) or sequelae . No antiviral therapeutics have yet received regulatory approval or demonstrated clinical efficacy. Here we describe the discovery of a novel anti-EBOV small molecule antiviral, GS-5734, a monophosphoramidate prodrug of an adenosine analog. GS-5734 exhibits potent antiviral activity against multiple variants of EBOV in cell-based assays.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 02, 2016
- Accession Number
- AD1003549
Entities
People
- Adrian S. Ray
- Amy C. Shurtleff
- Brett P. Eaton
- Bruce Ross
- Cary J. Retterer
- Catherine L. Wilhelmsen
- Christina F Spiropoulou
- Darius Babusis
- Dima Gharaibeh
- Donald K. Nichols
- Douglas L. Mayers
- Dustin Siegel
- Edward Doerffler
- Elizabeth Grimes
- Ernest Carra
- Ginger Donnelly
- Hon C. Hui
- Iva Transcheva
- Jay Wells
- Jonathan E. Nuss
- Joy Y. Feng
- Kelly S. Stuthman
- Kirsten M. Stray
- Kwon Chun
- Laura Gomba
- Laura K. Mcmullan
- Lijun Zhang
- Lisa S. Welch
- Lydia Wolfe
- Michael K. Lo
- Michael O. Clarke
- Michel Perron
- Mike Flint
- Molly R. Braun
- Nate Larson
- Nicole L. Garza
- Ona Baraskaus
- Pamela Wong
- Queenie Wang
- Rachel Fearns
- Richard L Mackman
- Robert Jordan
- Robert Strickley
- Rouzbeh Zamani
- Roy Bannister
- Sean A. Van Tongeren
- Sean Neville
- Shan-shan Chen
- Sina Bavari
- Stuart T. Nichol
- Swami Swaminathan
- Tara Kenny
- Tomas Cihlar
- Travis K. Warren
- Veronica Soloveva
- Willard Lew
- William A. Lee
- Yeojin Park
- Yili Xu
Organizations
- Boston University School of Medicine
- Centers for Disease Control and Prevention
- United States Army Medical Research Institute of Infectious Diseases