1,5 iodonaphthyl Azide Inactivated V3526 Protects against Aerosol Challenge with Virulent Venezuelan Equine Encephalitis Virus.

Abstract

Venezuelan equine encephalitis virus (VEEV) is a New World alphavirus. There is no licensed vaccine for prophylaxis against VEEV. VEEV is highly infectious in aerosolized form and has been identified as a bio-terrorism agent. The current IND vaccine is poorly immunogenic and does not protect against an aerosol challenge with virulent VEEV. We have previously shown that VEEV inactivated by 1,5 iodonaphthy azide (INA) protects against footpad challenge with virulent VEEV. In this study, we inactivated an attenuated strain of VEEV, V3526, with INA and evaluated its protective efficacy against aerosol challenge with virulent VEEV. We demonstrated that among three routes of immunization, intramuscular immunization with INA-inactivate V3526 provided complete protection against aerosol challenge with virulent VEEV. Our data suggests that INA-inactivated V3526 may be explored further for specific development as an effective vaccine candidate against aerosol challenge of virulent VEEV.

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Document Details

Document Type
Technical Report
Publication Date
Jun 02, 2016
Accession Number
AD1003556

Entities

People

  • Anuj Sharma
  • Jeffrey W. Cohen
  • Kevin B. Spurgers
  • Lori T. Eccleston
  • Pamela J Glass
  • Paridhi Gupta
  • Radha K. Maheshwari
  • Russell R. Bakken
  • Shelley P Honnold

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Blood
  • Body Weight
  • Cells
  • Chemistry
  • Department Of Defense
  • Ebola Virus
  • Encephalitis
  • Equine Encephalitis
  • Immunization
  • Immunogenicity
  • Infectious Diseases
  • Lymphocytes
  • Proteins
  • Vaccination
  • Vaccines
  • Virology
  • Viruses

Fields of Study

  • Biology

Readers

  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology