Towards a Molecular Understanding of Noise-Induced Hearing Loss

Abstract

The purpose of this project is to understand the inner ear cell type-specific changes induced by different types of noise and pre-conditioning interventions. To date, we have calibrated the noise exposures, and successfully completed tissue collection and processing for RNA-seq of baseline and noise treated samples at two different time points following noise exposure. We also established the sequencing conditions for all libraries and have been critically comparing the pre-conditioning treatments to carefully select the ones for further investigation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1004022

Entities

People

  • Ronna Hertzano

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Animals
  • Biological Sciences
  • Calibration
  • Cells
  • Cytoskeleton
  • Data Analysis
  • Department Of Defense
  • Ear
  • Gene Expression
  • Hearing Disorders
  • Hearing Loss
  • Intervention
  • Measurement
  • Medical Personnel
  • Professional Development
  • Tissues
  • Training

Readers

  • Auditory Neuroscience/Auditory Physiology.
  • Computational Modeling and Simulation
  • Molecular Genetics