Biomarkers for Autism and for Gastrointestinal and Sleep Problems in Autism

Abstract

The nighttime and daytime excretions of melatonin sulfate were not significantly different between typically developing (TD) toddlers and toddlers with autism spectrum disorders(ASDs). Sleep and gastrointestinal(GI)problems were not associated with lower melatonin excretion in TD or ASD toddlers and to a large extent these problems occurred at similar rates in the TD and ASD groups. The expected day-night differences in melatonin sulfate excretion, and in norepinephrine and epinephrine excretion, were seen in both groups. Thus, the lower melatonin production reported for older children with ASD does not appear to occur in toddlers with ASD.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2015
Accession Number
AD1004075

Entities

People

  • George M. Anderson

Organizations

  • Yale University

Tags

DTIC Thesaurus Topics

  • Autism
  • Biological Markers
  • Biological Rhythms
  • Data Analysis
  • Diseases And Disorders
  • Epinephrine
  • Excretion
  • Melatonin
  • Nervous System
  • Norepinephrine
  • Pain
  • Physiology
  • Production
  • Spectra
  • Statistics
  • Sympathetic Nervous System
  • Universities

Fields of Study

  • Medicine
  • Psychology

Readers

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  • Child and Adolescent Substance Abuse Science in Autism Spectrum Disorders.
  • Circadian Sleep-Wake Regulation and Chronobiology