Positioning Vascularized Composite Allotransplantation in the Spectrum of Transplantation
Abstract
We have continued our studies of the immune mechanisms contributing to rejection ofvascularized composite allografts (VCA) in murine models, and how these may be overcome to promote long-term allograft survival. We have now firmly established an orthotopic hind limb VCA model in our lab, and using this orthotopic model, have shown that either of 2 protocols, namely costimulation blockade (CD40L monoclonal antibody plus 2 weeks of rapamycin, RPM), or anti-TCR monoclonal antibody plus 2 weeks of RPM, can each achieve long-term VCA survival without maintenance immunosuppression. We are currently using these approaches to explore mechanistic details. Lastly, we have begun to test whether HDAC targeting may have effects on the VCA survival.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1004082
Entities
People
- Wayne W Hancock