Immunomodulation to Optimize Vascularized Composite Allograft Integration in Limb Loss Therapy

Abstract

The purpose of this study is to determine the safety and efficacy of hand transplantation as a treatment for patients with loss of limb below the elbow, The study will focus on patients who have had loss of limb. The primary endpoint is the ability to use the transplanted limb in activities of daily living at 18 months following transplantation measured by a quantitative functional test. Study activities include several study visits over 18 months and include; demographics, medical history, vital signs, psychosocial evaluation, urine, blood test, chest x-ray, bone density scans, and biopsies. Subjects who are 18-65 and willing to travel to site and have loss of limb will be included in study evaluation.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1004925

Entities

People

  • Linda Cendales

Organizations

  • Duke University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allografts
  • Biomedical Research
  • Body Armor
  • Casualties
  • Clinical Trials
  • Composite Materials
  • Department Of Defense
  • Diagnostic Techniques (Medicine)
  • Electronic Mail
  • Hematologic Tests
  • Immunomodulation
  • Institutional Review Board
  • Medical Personnel
  • Test And Evaluation
  • Therapy
  • Transplantation
  • Transplants

Fields of Study

  • Medicine

Readers

  • Neuroscience
  • Neurotrauma and Rehabilitation Medicine.
  • Oncology and Biomarker-Based Cancer Detection.

Technology Areas

  • Biotechnology