A Novel Mechanism for the Pathogenesis of Nonmelanoma Skin Cancer Resulting from Early Exposure to Ultraviolet Light
Abstract
Skin egress, entering the circulation, and traveling throughout the body may be a characteristic of skin stem cells. We have made several novel findings in this regard: 1) murine epidermal keratinocytes migrate preferentially in vitro to bone marrow cells, 2) keratinocytes migrate towards SDF1 alpha and HMGB1 baits over control attractants. 3) CD184 is expressed on approximately 27 percent of CD49f+/CD34+ hair follicle stem cells, and 4) CD49f+/Keratin 14+ cells in increase in blood and bone marrow following solar UV treatment. 5) Skin grafting studies demonstrated that grafted cells appear in bone marrow. 6) DMBA/TPA studies showed that keratinocytes migrated from the epidermis during the early stages of skin tumor promotion. 7) We demonstrated using our K14mTmG transgenic mice that a low but significant number of K14-expressing cells are found in the bone marrow. These findings support our hypothesis that: 1) skin egress may be a characteristic of skin stem cells in response to damage, and 2) bone marrow may be a long-lived reservoir of sunlight initiated stem cells that can repopulate the skin even years later following damage to the skin.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 2015
- Accession Number
- AD1005069
Entities
People
- Rebecca Morris
Organizations
- University of Minnesota