Demyelination as a Target for Cell-Based Therapy of Chronic Blast-Induced Traumatic Brain Injury

Abstract

The burden of traumatic brain injury (TBI) is expressed in the disabling behavioral and cognitive abnormalities noted in significant number of combat veterans. These clinical phenotypes suggest impairment in distributed cerebral functions dependent on the integrity of white matter (WM) tracts. In this proposal we explore mechanisms of mild blast trauma-associated demyelination, with the goal of testing a therapeutic strategy to enhance remyelination using human glial restricted progenitors (hGRPs; Q Therapeutics Inc.).

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1005075

Entities

People

  • Miroslaw Janowski

Organizations

  • Johns Hopkins University

Tags

DTIC Thesaurus Topics

  • Abnormalities
  • Abstracts
  • Biomedical Research
  • Blast Injuries
  • Brain
  • Brain Injuries
  • Cells
  • Cognitive Impairment
  • Data Analysis
  • Diseases And Disorders
  • Local Governments
  • Medical Personnel
  • Neurodegeneration
  • Neurodegenerative Diseases
  • Overpressure
  • Professional Development
  • Therapy

Fields of Study

  • Medicine
  • Psychology

Readers

  • Immunology and Pathology
  • Neurotrauma and Rehabilitation Medicine.