Tinnitus Multimodal Imaging
Abstract
Tinnitus is a common auditory perceptual disorder whose neural substrates are under intense debate. This project takes a multimodal imaging approach to better understand whole brain network connectivity abnormalities. Resting-state fMRI reveals increased corticostriatal connectivity isolated to area LC of the caudate, which is positioned at the junction of the head and body of the nucleus. Other patterns of increased connectivity include caudate head with cingulate gyrus of the default mode network. Those findings provide further evidence to support the striatal gating model of tinnitus, where dysfunctionally permissive area LC enables auditory phantoms to reach perceptual awareness. Magnetoencephalographic resting-state functional connectivity imaging (MEGI) in tinnitus subjects in the alpha-band shows increased connectivity in bilateral middle frontal gyrus (MFG), left postcentral gyrus, and left inferior parietal lobule. 7T MR spectroscopic imaging (MRSI) methods have successful capture of distinct GABA signals in the caudate nucleus and auditory cortices reliably.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1005118
Entities
People
- Srikantan S. Nagarajan
- Steven W. Cheung
Organizations
- University of California, San Francisco