Targeting Common but Complex Proteoglycans on Breast Cancer Cells and Stem Cells Using Evolutionary Refined Malaria Proteins

Abstract

We have successfully produced recombinant malaria derived VAR2CSA that binds with high affinity and high specificity to breast cancer cells and breast cancer tissue biopsies. We have demonstrated that the protein binds to distinct secondary modified proteoglycans exclusively present on breast cancer cells and that targeting these with recombinant VAR2CSAinterferes with key functions of the cancer cell like growth, migration and invasion. In vivo models demonstrate that conjugation of a toxin to VAR2CSA followed by IV administration to metastatic breast cancer bearing mice completely cures the animals.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2015
Accession Number
AD1005269

Entities

People

  • Ali Salanti

Organizations

  • University of Copenhagen

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cancer
  • Carcinoma
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Colon Cancer
  • Health Services
  • Lymphatic Diseases
  • Mass Spectrometry
  • Medical Personnel
  • Neoplasms
  • Oncology
  • Polysaccharides

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Immunology and Pathology
  • Molecular Genetics

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech