Promoter-Based Theranostics for Prostate Cancer

Abstract

This project leverages cancer-specific promoters for molecular-genetic endoradiotherapy and in the development of a universal blood test for cancer. The idea is to have the progression-elevated gene 3 promoter (PEG-Prom) and/or the astrocyte-elevated gene 1 promoter (AEG-Prom) serve to drive, in a cancer-specific manner, production of a thymidine kinase that can phosphorylate radiotherapeutic nucleosides, as well as drive -hCG, which can be detected using a commercial urine pregnancy test. The technology is based on our previously reported promoter-based cancer-specific imaging. The innovations of the project lie in its simplicity, use of non-viral vectors, systemic delivery and that it is a generalizable, platform technology.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1005313

Entities

People

  • Martin G. Pomper

Tags

DTIC Thesaurus Topics

  • Alpha Particles
  • Androgen Receptors
  • Biomedical Research
  • Blood
  • Cancer
  • Cells
  • Diseases And Disorders
  • Electronic Mail
  • Health Services
  • Magnetic Resonance
  • Medical Personnel
  • Neoplasms
  • Particles
  • Prostate
  • Prostate Cancer
  • Radiology
  • Therapy

Readers

  • Molecular Genetics

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech