The Risk and Clinical/Molecular Characteristics of Breast Cancer in Women with Neurofibromatosis Type 1

Abstract

The occurrence of breast cancer is increased in women affected with Neurofibromatosis type 1 (NF1). This study is aimed at identifying an accurate incidence of breast cancer in this group of women in a multi-center collaborative environment. There are 4 specific aims. Aim 1 is to confirm the increased breast cancer risk in women with NF1. Aim 2 is to analyze the germline NF1 gene and whole exome in the subjects with history of breast cancer. Aim 3 is to determine if NF1 associated breast cancers have unique characteristic signaling pathways or molecular tumorigenesis. Aim 4 is to study the phenotype of NF1 knockdown in primary mammary epithelial cells, specifically focused on the senescence effect due to Ras activation.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
AD1006231

Entities

People

  • Albert M Levin
  • Bruce R. Korf
  • Dhananjay A Chitale
  • Jaishri O Blakeley
  • Maria T. Acosta
  • Renee N. Tousignant
  • Xia Wang

Organizations

  • Henry Ford Health

Tags

DTIC Thesaurus Topics

  • African Americans
  • Breast Cancer
  • Cancer
  • Carcinoma
  • Data Analysis
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Medical Personnel
  • Neoplasms
  • Nervous System
  • Nervous System Neoplasms
  • Neuromuscular Diseases
  • Skin Diseases
  • Statistical Analysis

Readers

  • Molecular and Cellular Biology
  • Molecular and genetic basis of cancer.
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.