A Molecular Framework for Understanding DCIS

Abstract

This project centers on creating a molecular framework of DCIS (ductal carcinoma in situ). DCIS is considered to be the precursor to Invasive Ductal Carcinoma (IDC), the most common form of breast cancer. IDC accounts for 80% of all breast cancers, predominantly affecting women aged 55 and older; however, at least a third of women with IDC are diagnosed before they reach 55. Not all patients with DCIS will develop IDC however, we are looking for ways to better predict those patients that need life-saving treatment, and separate these from those patients who are less at risk.So far we have 2060 lesions dissected from freshly frozen biopsies, these have been annotated by our pathologist and prepared to be taken on for sequencing. The tissue includes DCIS, IDC, stroma adjacent to DCIS/IDC and normal tissue. We have initiated the RNA sequencing from these samples and also the DNA sequencing.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1006316

Entities

People

  • Gregory Hannon

Organizations

  • University of Cambridge

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Biomedical Information Systems
  • Biomedical Research
  • Breast Cancer
  • Carcinoma
  • Computational Biology
  • Diseases And Disorders
  • Dna Sequence Analysis
  • Genetic Structures
  • Medical Personnel
  • Neoplasms
  • New York
  • Physicians
  • Precursors
  • Professional Development
  • Rna Sequence Analysis
  • Tissues

Fields of Study

  • Medicine

Readers

  • Molecular Biology and Genetics
  • Trauma or Military Medicine
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.