Pathology Report for Intraperitoneal Sodium Dichromate Exposure in Rats, Protocol No. 15-002-3
Abstract
Hexavalent chromium is an oxidizing agent and known carcinogen that is extensively used. It affects the respiratory tract, gastrointestinal tract, liver, kidneys and immune system. To protect Soldier health, additional information on the mechanism of toxicity were sought. Groups of rats were given a single IP injection of saline vehicle or increasing doses of Na2Cr2O7, euthanized 1, 3, 7 or 14 days later, and tissues examined. Liver and kidney exhibited direct injury to the capsule and underlying parenchyma. Lesions were present 1 day after injection and persisted. This may be the first report in rats that suggests persistent injury after 1 exposure; underscoring the need for detection capability to prevent Soldier exposure.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 08, 2015
- Accession Number
- AD1006353
Entities
People
- Erica E. Carroll
Organizations
- United States Army Center for Health Promotion and Preventive Medicine