Optimization of Soft Tissue Management, Spacer Design, and Grafting Strategies for Large Segmental Bone Defects using the Chronic Caprine Tibial Defect Model

Abstract

This proposal addresses the treatment of segmental bone defects and methods that can be used to manipulate the Masquelet induced membrane to create a graft bed that optimizes bone regeneration. The results showed that scraping the inner surface of the induced membrane provided a highly desirable environment that promoted more bone regeneration by providing exposure of the autograft placed in the defect site to fresh blood and competing non-osteogenic cells.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 2015
Accession Number
AD1006379

Entities

People

  • Jonathan Forsberg

Organizations

  • Henry M. Jackson Foundation for the Advancement of Military Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Autografts
  • Bone Regeneration
  • Cartilage
  • Casualties
  • Connective Tissue
  • Environment
  • Gene Expression
  • Medical Personnel
  • Membranes
  • Military Medicine
  • Osteogenesis
  • Predictive Modeling
  • Soft Tissues
  • Statistical Analysis
  • Surgery
  • Tissues
  • Wounds And Injuries

Readers

  • Trauma Surgery or Emergency Medicine.