Imaging Prostate Cancer Microenvironment by Collagen Hybridization
Abstract
The major goal of the proposed work is to develop new PCa imaging methods based on the collagen mimetic peptide (CMP)- mediated structural interrogation of the collagens associated with invasive tumor. In this proposal, we propose to use collagen mimetic peptide (CMP) as a collagen targeting agents that will allow imaging of invasive PCa. Since CMP binds to unstructured collagens more readily, it is expected to exhibit selective affinity to metastatic PCa tumors known to contain processed and denatured collagens. The motivating hypothesis is that the CMPs ability to bind to collagen/denatured collagen can be used to image PCa in vivo as well as to determine the level of PCa malignancy.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1006395
Entities
People
- Michael S. Yu
Organizations
- University of Utah