In Vivo Photoacoustic Imaging of Prostate Cancer Using Targeted Contrast Agent
Abstract
Prostate specific antigen screening for prostate cancer is inexpensive, non-invasive and sensitive, but lacks specificity. The accuracy of confirmatory prostate biopsy is only 52% due to either the absence of tumor or the inability to precisely sample small tumors with the biopsy needles. Thus, there is an urgent need to develop methods to accurately image cancers within the prostate, to rule out cancer in men with false positive PSA elevation and to ensure successful biopsy for those with small cancers. Photoacoustic imaging is an emerging functional imaging technique that can detect and diagnose prostate cancer based on the near-infrared optical absorption of either endogenous tissue constituents or exogenous contrast agents. Although endogenous tissue constituents show promise, in order to implement photoacoustic imaging in the clinic, there is a need for increased tumor cell specificity, sensitivity and depth of imaging. To enhance the application of photoacoustic imaging for the detection of early stage prostate cancer, development of near infrared dyes - labeled RNA aptamer that recognizes the prostate specific cell surface protein - prostate specific membrane antigen is proposed to specifically image prostate-cancer. The design incorporates a high energy tunable laser as the source and an ultrasound linear array to detect the acoustic-lens-focused photoacoustic signals generated from the cancerous lesions within the prostate.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 2015
- Accession Number
- AD1006413
Entities
People
- Bhargava K. Chinni
- Hans Schmitthenner
- John Krolewski
- Kent Nastiuk
- Navalgund Rao
- Shalini Singh
- Vikram S. Dogra
Organizations
- University of Rochester