Dissecting the Roles of Brain Injury and Combat-Related Stress in Post-Traumatic Headache

Abstract

Military traumatic brain injury (TBI) typically involves blast exposure, and typically occurs in an environment of extreme stress. One of the most common and debilitating consequences of TBI is post-traumatic headache (PTH). Because both TBI and stress could contribute to PTH, we examine them together and separately, attempting to understand the mechanisms by which they generate PTH, and to develop new treatments for the disorder tailored to both injury and stress mechanisms.In the first year of this project, a significant portion our time has been spent in the ACURO approval process. We obtained ACURO approval in the middle of the third quarter of the calendar year. Prior to ACURO approval (on an unfunded basis) weset up the blast apparatus in our lab and began validation work in this new setting. Since ACURO approval, we have continued validation work for all of the modalities we will need in the project (blast, sensory physiology, and behavior) and begun experiments.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1006434

Entities

People

  • Dan Kaufmann
  • Jeremy Theriot
  • K. C. Brennan
  • Punam Sawant

Organizations

  • University of Utah

Tags

Communities of Interest

  • Human Systems
  • Materials and Manufacturing Processes

DTIC Thesaurus Topics

  • Biomedical Research
  • Blast
  • Blast Injuries
  • Blood
  • Body Weight
  • Brain Injuries
  • Diseases And Disorders
  • Field Tests
  • Headache Disorders
  • Medical Personnel
  • Military Personnel
  • Pain
  • Physiology
  • Students
  • Training
  • Validation
  • Wounds And Injuries

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neurotrauma and Rehabilitation Medicine.