Direct Test for Neuroinflammation with [11C]DAP-713-PET Scanning

Abstract

This project concerns the non-invasive detection of inflammation in the brains of individuals suffering from the Gulf War Illness (GWI). We are using quantitative positron emission tomography (PET) using [11C]DPA-713 (DPA). DPA binds to the translocator protein (TSPO), which is located on the outer mitochondrial membrane and is an established biomarker of neuroinflammation. The study intends to enroll 10 patients and 10 appropriately matched healthy control subjects. The study is a collaboration between Johns Hopkins University and the University of Texas Southwestern Medical Center, where a carefully vetted population of individuals with GWI exists. PET imaging will be undertaken at Johns Hopkins.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1006823

Entities

People

  • Jennifer Coughlin
  • Martin G. Pomper
  • Robert W. Haley
  • Yuchuan Wang

Organizations

  • Johns Hopkins University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Brain
  • Brain Injuries
  • Department Of Defense
  • Detection
  • Diseases And Disorders
  • Electronic Mail
  • Health Services
  • Imaging Techniques
  • Medical Personnel
  • Neuroimaging
  • Persian Gulf Syndrome
  • Positron Emission Tomography
  • Positron Emissions
  • Prostate Cancer
  • Test Methods
  • Therapy
  • Tomography

Readers

  • Gulf War Illness and Chronic Multisymptom Illness in Veterans.
  • Medical Imaging.
  • Research Science/Academic Research