Mesothelioma: Identification of the Key Molecular Events Triggered by BAP1

Abstract

We discovered that germline BAP1 mutations cause a novel cancer syndrome characterized by a very high incidence of MM. In some BAP1-mutation carrying families, MM accounts for more than 50% of deaths. We hypothesize that this may be due to increased susceptibility to MM from exposure to modest amounts of asbestos that would normally not cause MM in the population at large. In order to study the mechanism(s), we assembled a unique cohort and set of reagents. We have conducted a number of in vitro and in vivo experiments and obtained quite exciting results during this year. We found that BAP1 status regulate NF-kB activity and HMGB1 release, and we also found that monoallelic BAP1 loss increases susceptibility to low doses of asbestos by using a mouse model.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2014
Accession Number
AD1007000

Entities

People

  • Haining Yang

Organizations

  • University of HawaiĘ»i System

Tags

DTIC Thesaurus Topics

  • Asbestos
  • Biomedical Research
  • Cancer
  • Cell Physiological Processes
  • Cells
  • Culture Media
  • Diseases And Disorders
  • Fibers
  • Identification
  • Mesothelioma
  • Mineral Fibers
  • Minerals
  • Mutations
  • Neoplasms
  • Patent Applications
  • Patents
  • United States

Fields of Study

  • Biology

Readers

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