Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury

Abstract

In year 3 of the Award we have extended our work to finalize the testing of Compound 49b in the IGBP-3 pathway in a trauma model. Specifically, we have done experimentation on how the inflammatory signaling pathway of TNF-alpha interacts with IGFBP-3 signaling in the blast model. As part of the PI transition, we extended our studies into the systemic effects of Compound 49b after ocular blast injury and successfully generated a method for the isolation of retinal ganglion cells, which are critical for the visual output from the eye to the brain in health and ocular injury.

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Document Details

Document Type
Technical Report
Publication Date
Nov 01, 2015
Accession Number
AD1007135

Entities

People

  • Vanessa M. Morales-tirado

Organizations

  • University of Tennessee Health Science Center

Tags

DTIC Thesaurus Topics

  • Antigens
  • Blast Injuries
  • Blood
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Diseases And Disorders
  • Genetics
  • Health Services
  • Lymphocytes
  • Ophthalmology
  • Retinal Diseases

Fields of Study

  • Medicine

Readers

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