Systematic Characterization of the Molecular Mechanisms That Regulate and Mediate Alternative Lengthening of Telomeres in Breast Carcinoma

Abstract

Alternative lengthening of telomeres (ALT) is a mechanism utilized by several cancer types to maintain telomeres. The aim of this project is to characterize the mechanisms that mediate and regulate ALT activity in breast cancer, by utilizing proteomic and genomic approaches to describe and perturb ALT+ cells. Gaining this knowledge on ALT activity can promote the development of novel treatment for ALT+ breast tumors, and patients with telomerase inhibitor resistant tumors, while having minimal non-desired effects on the normal cell population that typically has no ALT activity. Here, I report on my progress in profiling and analyzing a collection of ALT+ and non-ALT cell-lines in order to define an ALT+ expression signature, which highlights potential mechanism and vulnerabilities of ALT+ cells. In addition, I report on the profiling of transcriptional changes that occur upon suppression of ATRX.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 2015
Accession Number
AD1007143

Entities

People

  • Yaara Zwang

Organizations

  • Dana–Farber Cancer Institute

Tags

DTIC Thesaurus Topics

  • Breast Cancer
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemical Synthesis
  • Chemistry
  • Chromosome Aberrations
  • Chromosome Structures
  • Chromosomes
  • Epithelial Cells
  • Gene Expression
  • Genetics
  • Medical Personnel
  • Neoplasms
  • Small Molecules
  • Tumor Cell Line
  • United States

Fields of Study

  • Biology

Readers

  • Breast cancer cell signaling and growth regulation.
  • Housing Policy Studies in Military Families with Privatization and Telomerase Allowance Units, Multi-Family Housing, and Telomere Lengths.
  • Molecular and Cellular Biology

Technology Areas

  • Biotechnology