Identifying Molecular Regulators of Neuronal Functions Affected in the Movement Disorder Dystonia
Abstract
The movement disorder dystonia is characterized by involuntary muscle contractions in the limbs, hands, feet or neck. The aim of the research proposed here is to identify the functional changes that occur in brain neurons of a mouse model of DYT1 dystonia. The most significant finding during this period is that the intracellular Ca2 dynamics in the axons and dendrites of cultured brain neurons were abnormal in the model mice. This result indicates that the pathophysiology of dystonia can involve dysregulation of Ca2 -mediated events, such as synaptic transmission in the brain.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 2015
- Accession Number
- AD1007174
Entities
People
- Nobutoshi C. Harata
Organizations
- University of Iowa