The Dynamics of the Human Infant Gut Microbiome in Development and in Progression Toward Type1 Diabetes
Abstract
Colonization of the fetal and infant gut microbiome results in dynamic changes in diversity, which can impact disease susceptibility. To examine the relationship between human gut microbiome dynamics throughout infancy and type 1diabetes (T1D), we examined a cohort of 33 infants genetically predisposed to T1D. Modeling trajectories of microbial abundances through infancy revealed a subset of microbial relationships shared across most subjects. Although strain composition of a given species was highly variable between individuals, it was stable within individuals throughout infancy. Metabolic composition and metabolic pathway abundance remained constant across time. A marked drop in alpha-diversity was observed in T1D progressors in the time window between seroconversion and T1D diagnosis, accompanied by spikes in inflammation-favoring organisms, gene functions, and serum and stool metabolites. This work identifies trends in the development of the human infant gut microbiome along with specific alterations that precede T1D onset and distinguish T1D progressors from nonprogressors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 09, 2016
- Accession Number
- AD1007182
Entities
People
- Aleksandar D. Kostic
- Aleksandr Peet
- Anu-maaria Hamalainen
- Clary B Clish
- Curtis Huttenhower
- Dirk Gevers
- Eric A. Franzosa
- Harri Lahdesmaki
- Heli Siljander
- Hermie Harmsen
- Ismo Mattila
- Matej Oresic
- Mikael Knip
- Outi Vaarala
- Paivi Poho
- Ramnik J. Xavier
- Suvi M. Virtanen
- Tommi Vatanen
- Tuulia Hyotylainen
- Vallo Tillmann
Organizations
- Harvard T.H. Chan School of Public Health