Supplemental Perioperative Oxygen to Reduce Surgical Site Infection After High Energy Fracture Surgery

Abstract

Our study is a multi-center prospective randomized treatment trial investigating if supplemental perioperative oxygen use will reduce surgical site infection after surgery on fractures with a high risk of infection. The study utilizes the DOD-funded Major Extremity Research Consortium (METRC). The study population is calcaneus, pilon, and tibial plateau fractures. During the first year we created a protocol committee, designed and approved the protocol and CRFs, obtained IRB approval. We have enrolled 427 patients to date at 18 centers. We have now reached a steady state of greater than 20 patients per month (278 this year). Follow up rate has been strong with 93 percent at 3 months and 86 percent at 6 months. The study is on track to complete enrollment in a reasonable time frame and there are no barriers to study completion.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 2015
Accession Number
AD1007200

Entities

People

  • Robert V. O'toole

Organizations

  • University of Maryland, Baltimore

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Consortiums
  • Department Of Defense
  • Diseases And Disorders
  • Energy
  • Foot Bones
  • High Energy
  • Infection
  • Lower Extremity
  • Medical Personnel
  • Physicians
  • Pilot Studies
  • Predictive Modeling
  • Public Health
  • Steady State
  • Training
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Clinical Trial Research.
  • Neurotrauma and Rehabilitation Medicine.