Compact Graphical Representation of Phylogenetic Data and Metadata with GraPh1An
Abstract
The increased availability of genomic and metagenomic data poses challenges at multiple analysis levels, including visualization of very large-scale microbial and microbial community data paired with rich metadata. We developed GraPhlAn (Graphical Phylogenetic Analysis), a computational tool that produces high-quality, compact visualizations of microbial genomes and metagenomes. This includes phylogenies spanning up to thousands of taxa,annotated with metadata ranging from microbial community abundances to microbial physiology or host and environmental phenotypes. GraPhlAn has been developed as an open-source command-driven tool in order to be easily integrated into complex, publication-quality bioinformatics pipelines. It can be executed either locally or through an online Galaxy web application. We present several examples including taxonomic and phylogenetic visualization of microbial communities, metabolic functions, and biomarker discovery that illustrate GraPhlAn's potential for modern microbial and community genomics.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 12, 2016
- Accession Number
- AD1007275
Entities
People
- Curtis Huttenhower
- Francesco Asnicar
- George Weingart
- Nicola Segata
- Timothy L. Tickle
Organizations
- Harvard T.H. Chan School of Public Health