Molecular Profiling of Intraductal Carcinoma of the Prostate
Abstract
Defined by the presence of malignant cells spreading within intact prostatic ducts and acini, intraductal carcinoma of the prostate (IDC-P) occurs almost exclusively in high Gleason grade and stage tumors and is a consistent independent risk factor for tumor progression and death. Importantly, however, IDC-P is currently systematically under-diagnosed in needle biopsies because it has significant morphologic overlap with another intraepithelial lesion, high grade prostatic intraepithelial neoplasia (HGPIN). We hypothesize that IDC-P represents progression of invasive high-risk prostate carcinoma, and thus is molecularly distinct from HGPIN. Herein, we have begun to conduct an unbiased, three-pronged set of experiments to definitively identify the molecular signature of IDC-P using a combination of protein, RNA, and DNA-based assays. Aim 1 of the project has been completed following HRPO approval (5-22-15) and results were recently published. Currently, we are working to finish Aims 2 and 3.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1007280
Entities
People
- Tamara L Lotan
Organizations
- Johns Hopkins University