A Gene Expression Profile of BRCAness That Predicts for Responsiveness to Platinum and PARP Inhibitors
Abstract
In this annual progress report of the work performed from 7/15/2014 to 7/14/2015, we: i)present data on a unique subset of ovarian cancers which are not BRCA like, i.e. not HR deficient and are resistant to PARPis but are sensitive to platinum. These tumors exhibit alterations in another DNA repair pathway called nucleotide excision repair (NER) pathway. ii)present data that HSP90-inhibitors which were identified via our BRCAness profile may sensitize PARPi-resistant xenograft models to PARPis. iii)update our progress on validating our profile in a cohort of molecularly defined BRCA-mutated and HR-proficient tumors.
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 2015
- Accession Number
- AD1007367
Entities
People
- Panagiotis A Konstantinopoulos