High-Resolution Radioluminescence Microscopy for the Study of Prostate Tissue Slice Cell Metabolism and Monitoring of Treatment Response

Abstract

Currently, prostate cancers are classified using the Gleason Grade system and immunohistochemistry. The shortcoming of this method is that it requires fixation, which kills the cells in the tissue sample. We want to develop an optical microscopy method that can provide a high resolution (a few cells) image of the local metabolism in prostate cancer tissue slice cultures (TSCs). Our hypothesis is that the local glucose concentration in prostate TSCs is correlated to the malignancy of the disease. We aim at developing a microscopy technology to image the uptake of radiotracers into prostate TSCs with a high resolution. This will yield additional information on the metabolic activity of the tissue, which may be used to improve staging of a biopsy or to study the uptake of new tracers in vivo.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 2015
Accession Number
AD1007376

Entities

People

  • Silvan Tuerkcan

Organizations

  • Stanford University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Algorithms
  • Beta Particles
  • Biomedical Research
  • Cancer
  • Department Of Defense
  • Detection
  • Films
  • High Resolution
  • Measurement
  • Medical Personnel
  • Metabolism
  • Microscopy
  • Neoplasms
  • Prostate
  • Prostate Cancer
  • Thin Films
  • Tissues

Readers

  • Medical Imaging.
  • Oncology and Biomarker-Based Cancer Detection.